Since the outbreak of the COVID-19 pandemic, Italy has played a proactive role in international initiatives aimed at countering health threats.^[1] The Italian strategy in the fight against the pandemic was pursued through cooperation in different multilateral fora. Firstly, Italy participated in multilateral efforts undertaken within the World Health Organization (WHO), the European Union (EU) and the G20 and supported initiatives to reform global health law through the adoption of a new binding instrument on pandemic preparedness and response. Furthermore, Italy committed to ensuring the success of international procurement mechanisms for vaccines’ supply to low- and middle-income countries and advocated for exemptions to the international patent system to increase vaccines’ production.